Pancreatic and biliary tract cancers are fatal malignancies, with a limited number of diagnostics tools, or effective systemic treatments. We are seeking a motivated PhD candidate to join our research team dedicated to improve early diagnostic tool and overcome cancer resistance through the identification and functional analysis of novel biomarkers.

This project will focus on uncovering the molecular underpinnings of pancreatic ductal adenocarcinoma cancer (PDAC) and cholangiocarcinoma, utilizing cutting-edge technologies such as next-generation sequencing, advanced proteomics and pharmacological studies. You will investigate genetic and epigenetic alterations, non-coding RNAs, and protein interactions that contribute to metastasis and therapeutic resistance.

The ultimate aim is to develop diagnostic and predictive biomarkers as well as new potential therapeutic targets, enhancing the efficacy of cancer treatments and improving patient outcomes. To achieve these aims, we collaborate closely with surgeons, oncologists, pathologists, and a multidisciplinary team of scientists supporting translational research at Amsterdam UMC.

You will study the omics characteristics of PDAC and cholangiocarcinoma cells and tissues as well as in patient plasma, prior and during treatment. In addition, you will participate in investigating clinical data which can improve diagnosis or predict treatment outcome.

If you are passionate about translational cancer research and aspire to make a significant impact, we encourage you to apply for this exciting opportunity.

Project-related tasks include:

• Omics and imaging analysis of tissues and liquid biopsy samples;
• In vitro experiments on the interactions between cancer and host cells;
• In vitro experiments on new drugs/combinations;
• Maintain accurate and detailed records of experiments;
• Data analyses and preparation of scientific publications;
• Co-supervision of trainees and students.

• MSc degree in medicine.
• Good organization skills and excellent Dutch and English communication and writing skills ability are required.
• Previous experience with cell culture as well as affinity with modern molecular biology and next-generation techniques is an advantage.
• Strong commitment, interest in working with drugs and desire to translate your results into the clinic are recommended.
• Able to work not only independently but also in an international multi-disciplinary research team.
• Self-motivation, scientific creativity and curiosity are essential.

• A flying start to your career in scientific research.
• Plenty of room for personal development with a wide range of training & development of academic skills.
• Working on large-scale and own research, with motivated colleagues
• An initial fulltime contract for 12 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 3 years.
• Salary scale 10 for BIG-registered doctors in the Netherlands: € 3.824 to € 5.504 gross per month, depending on qualifications and experience. Doctors who are not BIG-registered in the Netherlands are scaled in salary scale OIO: € 3.017 to € 3.824 gross per month.
• Holiday hours: 186,4 per year for fulltime and a possibility to save additional hours.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
• Now still a (partial) reimbursement of your public transport travel costs. From 1 October, for >7 km each way, 100% public transport reimbursement and, for private transport, €0.18 per km up to a maximum of 40 km each way.
• Do you prefer walking or cycling? Take advantage of our good bike scheme. And from 1 October, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

Amsterdam UMC

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical science research projects, legal support is also provided.

Watch the video to find out more.

You will work in a multidisciplinary team including molecular and cell biologists, pharmacologists, biostatisticians and clinicians. You will be part of a welcoming and international community that values your contributions, encourages collaboration, and provides a supportive environment for your research endeavors.