Research focus

We invite applications from researchers with a strong interest in liver tumors (hepatoblastoma, hepatocellular carcinoma [HCC]) and liver disorders that increase the risk of tumor formation in children. Our mission is to explore the underlying mechanisms of these conditions and develop cutting-edge therapeutic strategies to improve patient outcomes.

Innovative Techniques and Collaborative Environment

The project will focus on investigating tumor origin, development and heterogeneity, as well as identifying new therapeutics modalities. You will utilize advanced methodologies such as single-cell and spatial transcriptomics, whole genome sequencing, RNA therapeutics development, antibody/nanobody design and high-throughput screening. Additionally, we develop advanced organoid models to investigate potential treatment strategies.

Collaborations with the Single Cell Genomics Facility, Protein and Antibody Facility, High Throughput Screening Facility, and Big Data Core are key to our research, providing a stimulating environment for scientific discovery. Our extensive collaborations both within the Utrecht Science Park and with international institutions foster a dynamic and interdisciplinary research environment. We will align the specific research focus with the postdoctoral researcher’s interests and areas of expertise to ensure a rewarding and mutually beneficial experience.

Profile

• A PhD in life sciences or a related discipline.
• Expertise in one of the following areas:
  • Single-cell and spatial transcriptomics, whole genome sequencing analysis
  • Proteomics
  • Organoid models
  • RNA therapeutics, antibody development
  • CRISPR-based screening
  • Liver or cancer biology
• A robust publication record.
• Demonstrated motivation, creativity, and strong analytical skills.
• Excellent communication skills.

Fixed-term contract: 1 year, with possible extension.

Our job offer

We provide a full-time position (36 hours) in a stimulating research environment with ample opportunities for professional development.  You will initially be appointed for the duration of one year, with a possible extension. Your gross monthly salary will depend on your experience and background, starting in scale 60 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

The Princess Máxima Center

The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

We are dedicated to pioneering research in pediatric liver cancer and related diseases and are seeking a passionate and skilled individual to join our dynamic team. Your contributions will play a crucial role in advancing our understanding and developing innovative therapies for pediatric liver cancers and rare liver diseases.

The Peng Lab

Our focus is on childhood liver cancer, diseases, and regenerative medicine. Our goal is to unravel the molecular mechanisms that drive childhood liver cancer and to develop innovative therapeutic approaches. We have previously pioneered the method for 3D hepatocyte organoid culture, and we will continue to leverage this organoid technology to model diseases for therapeutic discovery.

Contact

Are you our new colleague? We are looking forward to meeting you! You can apply directly by clicking on the button at the bottom of this page. Please provide your resume and a short motivation letter. For more information about this position, or to arrange an informal chat, please contact Weng Chuan Peng. We will be happy to tell you more!

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.