Bioinformatician Pharmacology and Toxicology

Many drugs in women and pregnant women are prescribed off-label. Their efficacy and safety have not been adequately studied in these populations. Hence, children and pregnant women, and their fetuses, are at an increased risk of therapy failure or toxicity. Ultimately, we aim to generate dosing guidelines for children and pregnant women. Towards this goal, we aim to use published and real-world data combined with pharmacokinetic modeling and simulation. Are you our new colleague?

In this project, funded by the Bill and Melinda Gates Foundation, we aim to explore the combined use of physiology-based pharmacokinetic modeling with real world data from large (existing) electronic health record databases to establish best-evidence doses for children and pregnant women.

You are expected to work with our clinical scientists, PK modelers and pharmacists to answer questions related to efficacy and safety of selected drugs, for which personalized dosing are highly needed. Your goal is to extract and analyze real-world-data to support dosing regimens in children and pregnant women.

As well as collaborate with our Radboudumc group, the Dutch Pediatric Formulary as well as with scientific teams from the Bill & Melinda Gates Foundation and groups in the Netherlands, UK and USA.

Tasks and responsibilities

• Work with large datasets, so you are not afraid of large unstructured datasets.
• Work with Radboud PBPK scientists, pharmacists and clinicians to define critical questions that can be addressed or informed with real-world data.
• Work closely with Knowledge Integration team at the Bill & Melinda Gates Foundation to design and execute real-world-data analyses.
• Supervise bachelor, master and advise PhD students (minor task).
• Work according to FAIR principles.

Our new colleague have a M.Sc. or Ph.D. degree in (Bio)Medical/Pharmaceutical Sciences, Biostatistics/Bioinformatics or Computer Science. You are experienced with analyzing large datasets with meta-data using R and/or Python and with NLP and ML. You have SQL programming and tuning experience and knowledge of clinical pharmacology, pharmacokinetics and/or pediatrics, obstetrics would be advantageous. Furthermore, you are fluent in the English language.

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together.

• A gross monthly salary between € 3.359 and € 5.292 (scale 10) based on full-time employment.
• An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
• If you work irregular hours, you will receive an allowance.
• As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
• Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
• Discount on your supplementary health insurance. You can make use of two collective health insurance policies: UMC Health Insurance and CZ Collective. They offer many extras to stay vital and healthy, such as a prevention budget, workshops, and apps.
• We provide annual courses, both professional and personal.

In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.

You will be appointed at the Department of Pharmacy, the Division of Pharmacology and Toxicology. The Department of Pharmacy's research activities focus on the following research areas: special populations: Pediatrics and Obstetrics, pharmacology of antimicrobial agents (antiretrovirals, antifungals, antibiotics, and tuberculosis drugs) and oncology drugs. Furthermore, the department houses a state-of-the-art bioanalytical laboratory, a preclinical laboratory focused on drug transport and toxicity and an excellent pharmacometrics (PBPK and popPK) group. We have strong national and international collaborations to unravel translational pharmacological research questions.

You will be working with our Radboudumc group, the Dutch Pediatric Formulary as well as with scientific teams from the Bill & Melinda Gates Foundation and groups in the Netherlands, UK and USA .

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on health and healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc

Any questions? Please contact prof. dr. Saskia de Wildt, full professor. Use the Apply button to submit your application.