In our lab, we take a biomimetic approach to addressing fundamental questions about biological self-organization. We build experimental model systems using soft materials such as vesicles, colloids, emulsions, and polymers, that mimic specific features of living systems, such as the ability to self-organize, to move directionally, or to communicate chemically.
In this project, you will produce an experimental model of DNA-coated vesicles with controllable stickiness to learn about the role of adhesion changes on cell motion. To grow from a shapeless clump into an intact animal, cells must move by pushing each other out of the way. How strong the cells stick together plays an important role in this process, but it is unknown how exactly changes in their stickiness affect their movement. You will address this question.
Practically, you will work develop skills in microfluidics, DNA nanotechnology, microscopy, and image analysis to make and study the model system. You will also compare your findings to literature results from simulations and living cells.
You will join a diverse team of chemists, physicists, and biologists in the
Self-Organizing Soft Matter lab with a range of nationalities. Our lab encourages collaborations and teamwork and fosters an inclusive working environment.