Job Description When you age, your blood vessels lose their elastic properties. This age-related arterial stiffening plays a major role in the development of high blood pressure. In this PhD project, you will study arterial biomechanics with a focus on age-related arterial stiffening. You will explore different mechanisms that may cause this stiffening, including calcification, collagen deposition, elastin degradation, and changes in the arterial smooth muscle. To investigate this, you will study human arterial mechanics, both in vivo and in vitro.
Your project will be embedded within the Cardiovascular Research Institute Maastricht (CARIM), part of the Faculty of Health, Medicine, and Life Sciences at Maastricht University. Your primary appointment will be with the Dept. of Biomedical Engineering, where you will work directly with a core team of three PhD students, one postdoc, an assistant professor, and a full professor. Our diverse department hosts people from countries all over the world, including Bulgaria, Croatia, Egypt, India, Italy, Lebanon, and the Netherlands. We are committed to creating an open, team science environment for everybody to thrive. Because of the project’s multidisciplinarity, you will collaborate with colleagues from Cardiothoracic Surgery, Internal Medicine, and Biochemistry. In particular, an additional team member and supervisor (assistant professor) will be with the Dept. of Biochemistry.
In your PhD project, you will: - Conduct ex vivo and in vivo human tissue biomechanics studies.
- Work with a state-of-the-art measurement set-up (DynamX).
- Use computer modelling to process and interpret your experimental results.
- Collaborate closely with basic scientists, engineers, and medical doctors.