Predictions inform almost all our decisions (e.g., when choosing the bike over the bus, based on the predicted duration and weather conditions). Critically, sometimes unexpected changes in the world render our predictions invalid (e.g., nearby roadworks result in a longer-than-predicted trip duration). Normative Bayesian theory prescribes that after particularly surprising outcomes, existing beliefs should be updated quickly using the newly arriving information. What are the brain circuits that mediate the flexible updating of prior beliefs?
The project will test theory-driven hypotheses using an integrative, cross-species approach combining laminar ensemble recordings (single-unit resolution), multi-fiber photometry and optogenetics in mice, and laminar functional magnetic resonance imaging (fMRI) at 7 Tesla in humans. Mouse and human observers will undergo an identical statistical learning paradigm.
The project, led by dr. Mototaka Suzuki and dr. Jan Willem de Gee, is embedded in the Cognitive and Systems Neuroscience (CSN) group at the Swammerdam Institute for Life Sciences (SILS). You will receive top-notch interdisciplinary training which will prepare you well for a career in cognitive and systems neuroscience.
The mission of the
Cognitive and Systems Neuroscience group, one of the researchgroups of the Swammerdam Institute for Life Sciences, is to elucidate how neuronal networks distributed across the sensory neocortex, frontal cortex, hippocampal memory system and subcortical regions cooperate in perception, decision-making and memory processing. We are interested in questions such as how perceptual representations are formed and how perceptual decisions are made.
We employ state-of-the-art tools such as laminar ensemble recordings (single-unit resolution), 2-photon imaging, multi-fiber photometry, optogenetics, functional magnetic resonance imaging (fMRI; at 7 Tesla), electroencephalography and pupillometry.
What are you going to do? You are expected to design, plan, and perform experiments in mice and humans. Co-supervisors will help during every stage of the project, but your strong motivation and pro-active work ethic is required. You are expected to learn new techniques quickly, if necessary.
Tasks and responsibilities: - complete and defend a PhD thesis within the official appointment duration of four years;
- design, plan, and perform experiments and data analysis in an independent manner;
- critically analyze and interpret results;
- write manuscripts;
- present your results at (inter)national scientific meetings;
- collaborate with international and local researchers;
- participate in the Faculty of Science PhD training programme;
- assist in teaching undergraduates and Master students;
- co-supervise MSc/BSc students.