The heart is the first organ to function in the embryo, and its correct formation is vital for life. We study cardiac development in zebrafish, a powerful model organism. Thanks to its transparent embryos, fast development and genetic malleability, zebrafish offer unparalleled opportunities for high-resolution live imaging and genomic modification. Our lab has an established track record in this field, having made groundbreaking advances in understanding how the heart’s differentiation, growth and shape are controlled, using techniques such as live imaging, genetic screening, and single-cell transcriptomics.

In this project, we will investigate heart looping morphogenesis and its relationship to embryonic patterning, with a special focus on the formation of the left-right axis. Cutting-edge single-cell multiomics and 4D imaging techniques will help us unravel the genetic networks driving the asymmetric looping of the heart.

We are seeking a highly motivated and independent PhD candidate with a strong background in developmental biology or cell biology. Candidates with experience or interest in bioinformatics will have an advantage. You should hold a Master’s degree and possess excellent communication skills in English. A collaborative mindset and the desire to work in an international, diverse team are essential.

Fixed-term contract: 15 months.

Depending on education and experience the minimum salary is €[[salarisMin]] and the maximum salary is €[[salarisMax]] gross per month for a full-time appointment (scale [[ufoSchaal]] cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP.

The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment).

For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW.

Applying for a Certificate of Good Conduct can be part of the employment procedure.

Hubrecht Institute

The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. At the institute, more than 20 research groups perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) and is located on the Utrecht Science Park 'De Uithof'. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL).

Diversity & Inclusion
The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy.

For questions please contact j.bakkers@hubrecht.eu