Are you a junior scientist or a postdoc specializing in PBPK modeling? Join us and contribute to safer, more effective treatments for children and pregnant women. Make a significant impact on global health with our enthusiastic research team!

Many medications for children and pregnant women are often prescribed off-label, which indicates that their efficacy and safety in these populations have not been adequately studied. Consequently, both children and pregnant women, along with their fetuses, are at a greater risk of treatment failure or adverse effects. The project’s primary aim is to create dosing guidelines for these groups by utilizing alternative approaches to clinical trials.

Within the project, funded by the Bill and Melinda Gates Foundation, you will develop and use physiology-based pharmacokinetic models to establish best-evidence doses for children and pregnant women. Moreover, you will work on preparatory actions for the implementation of these newly generated dosing advices in (inter)national guidelines.

You will be embedded in an enthusiastic research group consisting of PhD students, research technicians, clinical scientists, PK modelers, and pharmacists to answer questions related to the efficacy and safety of drugs, for which personalized dosing is highly needed. This will ensure proper guidance and will allow you to build professional experience in this emerging field.

Tasks and responsibilities

• Design and conduct in silico pediatric and/or pregnancy PBPK models to study exposure to pharmaceuticals.
• Develop model informed dosing guidelines for medication prescription in special populations (e.g. pediatrics), using PBPK modeling.
• Explore the use of AI and/or machine-learning to support modeling and/or informing dosing guidelines
• Contribute to (international) workshops aimed at non-modelers to show the value of PBPK modeling in drug development and clinical practice.
• Prepare presentations and progress reports for scientific discussions internally, as well as externally with (international) scientists.
• Presenting of outcomes at (international) conferences. Writing of scientific abstracts and papers.

We are looking for a junior scientist or a postdoc with the following profile:

• Completed MSc or PhD in (bio)medical sciences, medical biology, pharmacology, toxicology or comparable field.
• You are experienced with modeling, specifically PBPK-models. Working experience with Simcyp modeling software is a plus.
• Good communication skills in English
• Knowledge of clinical pharmacology and pharmacokinetics. Pediatrics or obstetrics would be advantageous.
• Valid current working visa EU. If you are not a EU citizen please provide nationality and visa status.

Fixed-term contract: 1 year with a possible extension of 1 year.

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• A gross monthly salary between € 3.493 and € 5.504 (scale 10) for full-time employment (36 hours per week). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and, depending on the position, an allowance of 47% to 72% for working irregular hours.
• 172 vacation hours per year based on a 36-hour working week. (As of 1 January 2025, you will receive 176 vacation hours).

Radboudumc

The position is available within the Department of Pharmacy, Pharmacology and Toxicology. The department has three main tasks: research, education, and clinical consultation that all contribute to our mission of improving the safe and effective use of medicines and improve treatment of intoxications.

The Department of Pharmacy's research activities focus on the following research areas: special populations: Pediatrics and Obstetrics, pharmacology of antimicrobial agents (antiretrovirals, antifungals, antibiotics, and tuberculosis drugs) and oncology drugs and sustainable pharmacy.

Furthermore, the Department houses a state-of-the-art bioanalytical laboratory, a preclinical laboratory focused on drug transport and toxicity and an excellent pharmacometrics (PBPK and popPK) group. We have strong national and international collaborations to unravel translational pharmacological research questions.

Radboudumc
Welcome to Radboud university medical center (Radboudumc), where our research groups strive for innovative solutions that make impact on health and healthcare. We challenge the status quo to overcome current and future health challenges. Our goal is to shape the future of healthcare for generations to come. Our focus is on prevention, sustainability, and meaningful care, which we achieve through our in-depth understanding of disease mechanisms, clinical science, public health research, medical technology and data science. Our approach is centered on breakthroughs that can truly enhance personalized healthcare and public health.

At Radboudumc, a comprehensive range of research programs provide the compass for our research efforts. Each program has a clear goal, where collaboration within and outside our organization is highly valued. We integrate care, education and research in partnership with our patients to ensure that our research programs have significant impact on health and healthcare. We invite you to join us in our mission to create a healthy future for all.