This project focuses on understanding and targeting malignant rhabdoid tumors (MRT), aggressive childhood cancers characterized by mutations in BAF complex members. Using patient-derived organoid models, we aim to develop tools to elucidate molecular mechanisms of BAF complex restoration. We will evaluate epigenetic regulators as potential therapeutic targets and perform genome-wide characterization of treatment responses. We will apply deep learning to analyze patient-specific molecular changes.

The project is a close collaboration between the labs of Elzo de Wit (Netherlands Cancer Institute) and Jarno Drost (Princess Maxima Centre), as such you will be embedded in both groups. You are expected to work in close collaboration with a wet-lab PhD student.

We are seeking a talented and motivated PhD student to join our research team working on an exciting project in pediatric cancer biology and computational genomics.

Required Skills

• Strong background in bioinformatics, computational biology, or related field
• Proficiency in programming (e.g., Python, R)
• Experience with genomic data analysis (e.g., ATAC-seq, ChIP-seq, RNA-seq)
• Excellent analytical and problem-solving skills

Desired Qualifications

• MSc in Bioinformatics, Computational Biology, or related field
• Experience with cancer genomics or epigenetics

Fixed-term contract: 4 years, with a possibility for extension.

Compensation

• Cutting-edge research environment
• Interdisciplinary collaboration opportunities
• Access to state-of-the-art sequencing and computational resources
• Training in advanced genomics and machine learning techniques

Join us in our mission to uncover fundamental processes in epigenetic regulation and develop better treatments for children with MRT.

You will be employed for a period of at least four years, with a possibility for extension. For a PhD student the gross salary per month can range from € 3.523,- to €4.277,- (salary PhD student scale, according to the Collective Labour Agreement General Hospitals), depending on your experience.  The terms of employment will be in accordance with the CAO Hospitals.

The Netherlands Cancer Institute

The Netherlands Cancer Institute is among the world’s best comprehensive cancer centers, combining innovative fundamental, translational, and clinical research with dedicated patient care. Our research institute gratefully acknowledges funding from the Dutch Ministry of Health, Welfare and Sport, the Dutch Cancer Society, and individual donors.

Contact
Your application letter, CV and contact information of 2 references can be attached to the application form via the orange sollicitationbutton.

This vacancy is open until 1st of Februari 2025. 
For further information about the position please contact Dr. Elzo de Wit ( +31 20 512 7864; e.d.wit@nki.nl) or Dr. Jarno Drost (+31 (0)88 9725503; J.Drost@prinsesmaximacentrum.nl)

The Netherlands Cancer Institute is an equal opportunity employer and values diversity in its workforce.