Research assistant- discovering the underlying biology of epilepsy

Epilepsy significantly impacts a patient's quality of life, leading to constant fear of the next seizure. For patients who do not achieve seizure freedom under medication, brain surgery can offer a chance at seizure freedom and a normal life. Epileptogenic tissue is characterized by high frequency oscillatory (HFOs) activity and intra-operative recording of HFOs guides neurosurgeons during tissue resection. However, the use of HFOs as biomarkers is not universally accepted yet, partly because its underlying neurobiology is neither clear nor validated. In the current project we aim to unravel this.

As a research assistant, we would supply you with the resected brain tissue. In this resected tissue you would (after training) analyze the occurrence of HFOs using an electrode grid (high density Multi Electrode array. Moreover, you would analyze these neurophysiological data, as well as data that were previously obtained from the brain during epilepsy surgery (intra-operative EEG). You would also perform recordings in new model systems for the human (epileptic) brain, using organoid systems.

In consultation with the project coordinators, there is a certain flexibility to determine the exact hours per week and the timing of your work (though on average it will be a part-time 0.6 fte position). This will always be based on the agreed-upon number of hours per month and the desired tasks/priorities.

We are looking for an enthusiastic, independent, detail-oriented, and intrinsically motivated research assistant with a (technical) medical or biology background, who enjoys making a substantial contribution to the acquisition, processing and analysis of neurobiological data for scientific research on epilepsy.

• Bachelor's or Master's degree in (Technical) Medicine, Biomedical Engineering, (Neuro)biology, or equivalent field.
• Fluent in English is a must, Dutch speaking preferred.
• Prior experience with (or proven affinity for) neurophysiological data acquisition or analysis is a plus.
• Prior experience in signal analysis and script writing, especially in Matlab or Python, is preferred.
• An analytical background is a plus, with an ideal candidate possessing both biology and analytical skills.
• Field of Expertise: Epilepsy, Neurology & Neurosurgery, Biology, Electrophysiology, Signal processing.

The maximum salary for this position (21 - 22 hours) is € 4.214,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

This research project is a collaboration between the Epilab research group – part of the Department of Neurology & Neurosurgery (prof. dr. Maeike Zijlmans, technisch geneeskundige assist dr. Maryse van ‘t Klooster) and the Department of Translational Neuroscience (dr. Frank Meye, dr. Christiaan Huffels). The functional epilepsy and epilepsy surgery department has a strong track record of leading research in invasive EEG recordings and epilepsy surgery. The Department of Translational Neuroscience offers state-of-the-art facilities and expertise, including the MIND facility for iPSC technology and brain organoids. You will be embedded within the two diverse, young, and friendly research groups, and collaborate with a multidisciplinary team of doctors, scientists, lab technicians, and patients themselves. Besides work, there is also a focus on a positive atmosphere in the workplace and social activities.